Retatrutide: The Triple-Agonist Fat Loss Peptide
Retatrutide (LY3437943) is a novel triple-agonist peptide developed by Eli Lilly that simultaneously activates three metabolic receptors: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR). This triple-receptor approach distinguishes it from dual-agonists like tirzepatide (GIP/GLP-1) and single-agonists like semaglutide (GLP-1 only).
Mechanism of Action
Retatrutide binds human GCGR, GIPR, and GLP-1R with EC₅₀ values of 5.79, 0.0643, and 0.775 nM, respectively. The triple-receptor activation creates a synergistic metabolic effect: GLP-1R activation suppresses appetite and slows gastric emptying; GIPR activation enhances glucose-dependent insulin secretion; GCGR activation stimulates hepatic glycogenolysis, gluconeogenesis, and energy expenditure — adding a direct fat-burning pathway that other GLP-1 drugs lack.
Clinical Trial Results
In phase 2 clinical trials, retatrutide produced mean body weight reductions of 15–24% over 48–72 weeks depending on dose and study population. Adverse events were primarily gastrointestinal (nausea, diarrhea), with low rates of discontinuation and no significant cardiovascular or hepatic events reported. Retatrutide is currently in phase 3 trials.
Role in the Ascension Stack
Within the Clavicular Ascension Stack, retatrutide serves as the primary metabolic and body recomposition compound. It pairs with testosterone cypionate and anavar for lean tissue preservation during aggressive fat loss, with BPC-157 and TB-500 for tissue protection, and with L-glutathione and NAD+ for antioxidant and metabolic support.
Clavicular Ascension Stack — 12 Compounds
All compounds available from QSC with ≥99% HPLC purity, Janoshik COA, and domestic shipping from 5 warehouse regions.
Get the Ascension Stack at QSC →Key Specifications
- CAS Number: 2381089-83-2
- Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
- Molecular Weight: 4731.33 g/mol
- Receptor Targets: GLP-1R, GIPR, GCGR (triple agonist)
- Form: Lyophilized powder, 10mg per vial
- Storage: Refrigerated 2–8°C, protect from light
Buy Retatrutide at QSC — ≥99% HPLC purity, Janoshik COA, domestic shipping.